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小剂量奥氮平辅助治疗难治性强迫症疗效观察

The effect of low dosage olanzapine as the adjunctive treatment to the patients with treatment resistant obsessive compulsive disorder

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【作者】 朴胜斌刘奋张文顺杨海晨高欢

【Author】 PIAO Sheng-bin,LIU Fen,ZHENG Wen-sun,et al (Shenzhen Kangning Hospital,Guangdong 518020,China)

【机构】 广东省深圳市康宁医院广东省深圳市康宁医院 广东深圳518020广东深圳518020

【摘要】 目的:探讨奥氮平辅助治疗难治性强迫症的临床疗效和安全性。方法:对28例难治性强迫症患者在原用药物基础上联合小剂量(5~10 mg/d)奥氮平治疗;奥氮平日剂量平均为(5.98±1.95)mg,疗程6周;在治疗前及治疗后6周末分别评定Yale-Brown强迫量表、Marks强迫恐怖量表、汉米尔顿焦虑量表、副反应评定量表,并检测体型指数、血糖、血脂变化等;对数据进行统计分析。结果:治疗后6周末Yale-Brown强迫量表、Marks恐怖强迫量表、汉米尔顿焦虑量表与治疗前比较均有显著性差异(P<0.01)。治疗6周末体型指数比治疗前有显著性差异(P<0.05)。结论:合用小剂量奥氮平治疗难治性强迫症疗效明确,但须注意体重变化。

【Abstract】 Objective:To investigate the effect and tolerance of low dosage olanzapine as the adjunctive treatment to the patients with treatment resistant obsessive compulsive disorder(OCD).Methods:Low dosage of olanzapine(5-10mg/d) were added to the former treatment scheme in 28 patients with treatment resistant OCD in 6 weeks.The mean dosage of olanzapine was 5.98±1.95mg/d.The Yale-Brown obsession compulsion scale,Marks phobia compulsion scale,Hamilton rating scale for anxiety,the side effect scale were assessed at the baseline and the end of the sixth week.The body indexes, glucose of blood,lipids of blood were also collected.Results: There were significant difference between the scores at the baseline and sixth week in the Yale-Brown obsession compulsion scale,Marks phobia compulsion scale,HAMA.The body index between baseline and the end of sixth week were also significant.Conclusions: It is useful to add low dosage of olanzapine to the patients with treatment resistant OCD.But the change of weight should be paid attention to.

  • 【文献出处】 中国民康医学 ,Medical Journal of Chinese People’s Health , 编辑部邮箱 ,2007年11期
  • 【分类号】R749.7
  • 【下载频次】45
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