【摘要】 调节性T(regulatoryT,Treg)细胞是一群具有抑制其他免疫细胞功能的负调控细胞,包括CD4+Treg、CD8+Treg、NKTTreg和双阴性(doublenegative,DN)Treg细胞等四大类。研究显示,肿瘤微环境中Treg细胞数量升高,且这些升高的Treg细胞能抑制抗肿瘤免疫、降低肿瘤免疫治疗的效果。寻找肿瘤微环境中Treg细胞升高的原因及清除Treg细胞的方法,已经成为肿瘤免疫的研究热点。现已证实,肿瘤可诱导肿瘤特异性Treg细胞的产生、肿瘤特异性CD4+CD25+Treg细胞在肿瘤局部募集和扩增、普通CD4+CD25-T细胞向Treg细胞的转化可能是肿瘤微环境中的Treg细胞数量升高的原因。抗CD25抗体能清除Treg细胞,但也同时清除了活化的效应细胞;新近发现,某些TLR信号通路的活化可抑制Treg细胞的功能,该发现为联合应用某些TLR配体和抗原肽改善肿瘤免疫治疗效果提供了新的思路。更多还原

【Abstract】 Regulatory T(Treg) cells are a group of negative regulatory cells,which have potent ability to suppress the functions of other immune cells.Treg cells have four subsets:CD4+ Treg,CD8+ Treg,NKT Treg and double negative(DN)Treg cells.However,recent studies demonstrated that there were an increased number of Treg cells in the tumor microenvironment,which could inhibit antitumor immunity and decrease the effect of immunotherapy to tumor.The cause of increased Treg cells in tumor microenvironment and designing the vaccine eliminating Treg cells have become new focuses in field of anti-tumor immunotherapy.It has been identified recently that tumor cells could induce the production of tumor specific Treg cells.The accumulation and expansion of tumor specific Treg cells in tumor and conversion of conventional CD4+ CD25-T cells to Treg cells may contribute to the increased number of Treg cells in tumor microenvironment.Treatment with anti-CD25 antibodies can not only eliminate Treg cells,but also deplete activated effector T cells.The recent findings indicate that activation of some signal pathways for toll-like receptor is able to inhibit the function of Treg cells,which might offer a new opportunity to improve the outcome of cancer immunotherapy by coadministration of certain toll-like receptor ligands and antigenic peptides.更多还原