【摘要】 GCLE是合成头孢类抗生素的一种重要的中间体,3-(氯甲基)-2-(3-苯乙酰胺-4-硫代苯磺酰-2-β-丙内酰胺-1-基)-3-丁烯酸对甲氧基苄酯经过一步反应即可得到GCLE。本文以自制3-甲基-2-(3-苯乙酰胺-4-硫代苯磺酰-2-β-丙内酰胺-1-基)-3-丁烯酸对甲氧基苄酯为原料,采用电解法得到目标产品。通过元素分析、IR对其结构进行表征,并用HPLC测定其含量。结果显示,此法合成GCLE工艺简单,收率高。更多还原

【Abstract】 Chlorinated-β-lactam dervatives are important intermediates in the manufacture of cephalosporin.This paper describes the procedure of chlorinated-β-lactam dervative(p-methoxybenzyl 2-(3-phenylacetamido-4-phenylsulfonylthio-2-β-lactam-2-en-1-yl)-3-chloromethyl-3-butenoate with β-lactam dervative p-methoxybenzyl 2-(3-phenylacetamido-4-phenylsulfonylthio-2-β-lactam-2-en-1-yl)-3-methyl-3-butenoate via electrolysis. The product was characterized by IR and elemental analysis and assayed by HPLC. The preparation procedure is efficient and with high yields.更多还原