【摘要】 目的:研究有氧运动对心理应激衰老大鼠行为和外周血氧自由基的影响。方法:健康雌性SD大鼠28只,随机分为对照组、运动组、心理应激组、运动+心理应激组,实验后测定大鼠的开场行为和外周血自由基的变化情况。结果::①开场行为:在穿越格数上运动组、心理应激组、运动+心理应激组与对照组相比较均有显著的增加(P<0.05),在站立次数上心理应激组、运动+心理应激组与对照组及运动组相比较有显著减少(P<0.01)。②血清中SOD活性、H2O2含量:各组间均无明显差异性;MDA含量:运动组、运动+心理应激组与对照组及心理应激组相比较有明显的减少(P<0.05);过氧化氢酶(CAT)活性:运动组的CAT活性明显高于心理应激组(P<0.05);GSH-px活性:与对照组相比较,运动组、运动+心理应激组的活性明显增加(P<0.05),心理应激组则明显降低(P<0.05)。结论:不适宜的心理应激可对动物的自发行为和探究行为产生影响,并可诱发机体内自由基量的增加而导致机体损伤,而通过有氧运动可减轻心理应激对机体产生的影响。更多还原

【Abstract】 Objective: To investigate the effect of aerobics on the free radicals in peripheral blood of aging rats after being received psychological stress.Methods: Twenty eight healthy female SD rats were divided into four groups at random:controlled(C) group,receiving swimming training for 60 mins(S),only getting psychological stress(P),receiving swimming training for 60 mins and psychological stress(P+S).The open-field test and the oxygen free radicals in peripheral blood of SD rats were determined. Results: ① Compared with C group,the numbers of crossing in other groups were significantly higher(P<0.05);the numbers of rearing in P and P+S group were significantly lower than that in C and P group(P<0.01).② the SOD activity and the H2O2 concentration in each group were no significant difference;compared with the C and P groups the MDA concentration in S and P+S groups were significantly decreased(P<0.05);compared with the P group the CAT activity in S group were significantly increased(P<0.05);compared with the C group the activity of GSH-px in S and P+S groups were significantly increased(P<0.05),but the activity of GSH-px in P group were significantly decreased(P<0.05). Conclusion: The unwell proper psychological stress can affect the self-moving behavior and the exploring behavior of the animal,and induce the increment of the free radicals inside the body which hurt the body;and the aerobics can alleviate the effect of the psychological stress in the body.更多还原