【摘要】 目的探讨阿托伐他汀对已接受降压治疗高血压病患者血压的影响。方法选取2003年3月至2005年5月在我院老年病区住院且出院后门诊随访、规律服用降压药物治疗的患者84例,按10年心血管危险分层及低密度脂蛋白胆固醇(LDL-C)水平分为对照组(35例)和治疗组(49例),对照组给予常规降压治疗,治疗组每晚加服阿托伐他汀从10mg始,根据血脂水平调整剂量,平均为(14.4±6.4)mg/d。两组在治疗前及治疗6个月、1年时分别予肱动脉血压测量和动态血压监测,并记录24h平均心率(HR)。结果对照组治疗前后血压无明显变化(均P>0.05);治疗组肱动脉收缩压(SBP)、脉压(PP),24h平均SBP、平均PP在治疗6个月及1年时均较治疗前下降,差异均具有统计学意义(均P<0.05),舒张压(DBP)、HR及24h平均DBP治疗前后无显著变化(均P>0.05)。结论阿托伐他汀对高血压患者具有降低SBP、缩小PP的作用。更多还原

【Abstract】 Objective To investigate the effect of atorvastatin on blood pressure in patients with essential hypertension.Methods Eighty-four inpatients or follow-up out patient with essential hypertension treated with regular antihypertensive drugs were assigned into two groups:control group(35 cases)and atorvastatin group(49 cases).Both control and atorvastatin groups took regular antihypertensive drugs,but the latter took additional atorvastain from 10mg to 40 mg,mean(14.4±6.4)mg/d,depending on blood lipid levels.Brachial blood pressure and ambulatory blood pressure monitoring(ABPM)were measured before and six months or one year after treatment.Results No change of all measurements in control group was found after treatment.In atorvastatin group,brachial SBP,brachial PP and 24h mean SBP,24h mean PP of ABPM decreased significantly(P<0.05).Six months and one year after treatment,there was no difference in diastolic blood pressure and heart rate.Conclusion Atorvastatin can reduce SBP and pulse pressure in the patients of hypertension.更多还原