【摘要】 目的比较甲泼尼龙(甲强龙)与地塞米松对治疗支气管哮喘重度发作的临床价值。方法将2003-05～2007-03在我科住院治疗的支气管哮喘重度发作患者89例随机分为两组,治疗组44例,对照组45例;两组均在常规治疗相同基础上,治疗组加用甲泼尼龙80mg/次,2次/d静点;对照组加用地塞米松15mg/次,2次/d静点,治疗前、治疗第3天分别记录症状、体征,测定动脉血气情况,进行相关统计学分析。结果治疗前两组患者支气管哮喘均为重度发作,两组差异无统计学意义;动脉血气分析:PaO2平均值两组比较差异无统计学意义(P>0.05);治疗第3天治疗组完全缓解率为93.2%(41/44),对照组缓解率为68.9%(31/45),两组比较差异有统计学意义(P<0.01);治疗组PaO2值为(87.1±7.4)mmHg,对照组PaO2值为(69.5±6.8)mmHg,治疗后两组PaO2比较有统计学意义(P<0.05)。结论在治疗支气管哮喘重度发作过程中甲强龙早期缓解哮喘的疗效更佳,有可能缩短住院日期。更多还原

【Abstract】 Objective To study the treatment of severe attack of bronchial asthma with methylprednisolone and dexamethasone.Methods 89 inpatients with severe attack of bronchial asthma admitted into our hospital from May 2003 to March 2007 were divided into two groups.The treatment group included 44 patients and control group included 45 patients.Besides conventional therapy for two groups,the treatment group was given methylprednisolone 80 mg/time,2 times/day and control group was given dexamethasone 15 mg/time,2 times/day.The symptom and sign,the arterial blood gas were recorded before the treatment and on the 3rd day after the treatment and analysed.Result Before the treatment,all the patients of two groups were severe attack of bronchial asthma and there was no statistical difference.Mean PaO2 of two groups was compared and the difference was not significant(P>0.05).The rate of perfect effectiveness was 93.2%(41/44)in treatment group and 68.9%(31/45)in control group on the 3rd day after the treatment and there was statistical difference in two groups(P<0.01).PaO2 in treatment group was(87.1±7.4)mm Hg and(69.5±6.8)mm Hg in control group and there was statistical difference(P<0.05).Conclusion Methylprednisolone has better effectiveness in the treatment of severe attack of bronchial asthma,and may shorten the time in hospital.更多还原