【摘要】 目的探讨N-末端脑钠肽(Nt-proBNP)在急性呼吸困难中的鉴别诊断价值。方法用ELISA法测定128例急性呼吸困难患者血浆Nt-proBNP,包括心源性呼吸困难和非心源性呼吸困难,观察两种急性呼吸困难患者血浆Nt-proBNP的浓度。结果充血性心力衰竭(CHF)引起的急性呼吸困难患者Nt-proBNP浓度明显高于非CHF组患者(P<0.01);CHF组Nt-proBNP浓度在心功能不同级别间差异有统计学意义,与左室射血分数呈负相关。结论Nt-proBNP可作为心源性呼吸困难患者鉴别诊断的一个观察指标,方法简单快速、敏感性高、特异性高。更多还原

【Abstract】 Objective To investigate the value of Nt-proBNP in the differentiation of dyspnea.Methods The Nt-proBNP of 128 patients suffered from dyspnea which caused by heart failure or non-heart failure were measured by ELISA and compared.Results The Nt-proBNP level of the patients whose dyspnea were caused by heart failure were obviously higher than those of patients whose dyspnea were caused by non-heart failure(P<0.01).The level of Nt-proBNP was significantly different at their different stages of heart function in congestive heart failure(CHF)group and negatively correlated with left ventricular ejection fraction(LVEF).Conclusion Nt-proBNP can be used as the indicator in the differential diagnosis of dyspnea because of it’s highly sensitivity and specificity.更多还原