【摘要】 目的了解胆石症患者胆汁中病原菌的分布及抗菌药物的敏感性,指导临床选择抗菌药物。方法对546例胆汁标本的细菌培养及药敏试验结果进行统计分析。结果有332例检出病原菌,阳性率为60.81%,前3位病原菌分别为大肠埃希菌(32.96%)、粪肠球菌(12.74%)、肺炎克雷伯菌(9.97%);病原菌对三、四代头孢菌素、β-内酰胺类复合制剂、碳青酶烯类、氨基糖苷类抗菌药物敏感性高,对青霉素类、一、二代头孢菌素、大环内酯类、喹诺酮类抗菌药物敏感性低。结论胆汁中病原菌种类繁多,以大肠埃希菌、粪肠球菌、肺炎克雷伯菌多见,真菌、厌氧菌的感染也不容忽视,临床应加强病原菌检测,依据药敏选择抗菌药物。更多还原

【Abstract】 OBJECTIVE To survey the distribution of the pathogenic microorganisms in biles collected from cholelithiasis patients and their susceptibility to antibiotics,to guide the selection of reasonable antibiotics.METHODS Totally 546 bile samples were cultured and tested for antibiotics susceptibility.RESULTS Bacteria were cultured from 332 samples with a positive rate of 60.81%,the first three were Escherichia coli(32.96%),Enterococcus faecalis(12.74%),and Klebsiella pneumoniae(9.97%).The pathogenic microorganisms were more sensitive to the third and fourth generation cephalosporins,antibiotic/βlactamase inhibitor combination,carbopenems and aminoglycosides antibiotics,while less sensitive to the first and second generation cephalosporins,penicillins,macrolide antibiotics and fluoroquinolones.CONCLUSIONS The pathogenic microorganisms in bile are very various,E.coli,E.faecalis and K.pneumoniae are usually cultured,fungous and anaerobic infections cannot be ignored.Doctors should pay more attention to analyze the bacterial resistance profile and use the antibiotics properly.更多还原