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内凝聚法制备姜油树脂海藻酸钙微囊
Preparation of Calcium Alginate Microcapsules Loaded with Ginger Oleoresin by Internal Gelation Method
【摘要】 <正>姜科植物姜(Zingiber officinale Roscoe)的干燥根茎具有抗氧化、降胆固醇、抗运动病、止痛抗炎及止吐等多种药理作用[1]。用超临界CO2萃取得
【Abstract】 The ginger oleoresin microcapsules were prepared by emulsification-internal gelation technique using sodium alginate as material.In vitro release behavior of the microcapsules was investigated under HCl and PBS.The results showed that the microcapsules observed with scanning electron microscope were spherical with mean diameter of(50.35±0.42)μm,span of 0.83±0.07 and drug entrapped efficiency of(45.3±0.4)% determined by UV method.The accumulative released amount was less than 10% in pH 1.2 hydrochloric acid within first 2h,but was up to about 83% in pH 7.4 phosphate buffer solution in the following 4h.The product had the characteristic to dissolve the intestines.
【Key words】 ginger oleoresin; calcium alginate microcapsule; emulsification-internal gelation technique; in vitro release;
- 【文献出处】 中国医药工业杂志 ,Chinese Journal of Pharmaceuticals , 编辑部邮箱 ,2007年04期
- 【分类号】TQ463
- 【被引频次】3
- 【下载频次】188