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内凝聚法制备姜油树脂海藻酸钙微囊

Preparation of Calcium Alginate Microcapsules Loaded with Ginger Oleoresin by Internal Gelation Method

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【作者】 刘利萍毛威王秀珍裘汉幸

【Author】 LIU Li-ping1,MAO Wei2,WANG Xiu-zhen1,QIU Han-xing2(1.Dept.of Pharmacy,College of Chemistry and Chemical Engineering,Shaoxing University;2.Shaoxing Institute for Drug Control,Shaoxing 312000)

【机构】 绍兴文理学院化学化工学院药学系绍兴市药品检验所绍兴市药品检验所 浙江绍兴312000浙江绍兴312000

【摘要】 <正>姜科植物姜(Zingiber officinale Roscoe)的干燥根茎具有抗氧化、降胆固醇、抗运动病、止痛抗炎及止吐等多种药理作用[1]。用超临界CO2萃取得

【Abstract】 The ginger oleoresin microcapsules were prepared by emulsification-internal gelation technique using sodium alginate as material.In vitro release behavior of the microcapsules was investigated under HCl and PBS.The results showed that the microcapsules observed with scanning electron microscope were spherical with mean diameter of(50.35±0.42)μm,span of 0.83±0.07 and drug entrapped efficiency of(45.3±0.4)% determined by UV method.The accumulative released amount was less than 10% in pH 1.2 hydrochloric acid within first 2h,but was up to about 83% in pH 7.4 phosphate buffer solution in the following 4h.The product had the characteristic to dissolve the intestines.

【基金】 浙江省青年教师2004年资助计划项目(浙教高科[2004]281)
  • 【文献出处】 中国医药工业杂志 ,Chinese Journal of Pharmaceuticals , 编辑部邮箱 ,2007年04期
  • 【分类号】TQ463
  • 【被引频次】3
  • 【下载频次】188
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