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黄芪甲苷-羟丙基-β-环糊精包合物的制备
Preparation of Hydroxypropyl-β-cyclodextrin Inclusion with Astragaloside Ⅳ
【摘要】 制备并鉴定了黄芪甲苷与羟丙基-β-环糊精的包合物。试验表明,包合物中黄芪甲苷的平均含量为20.4%,25℃时溶解度由22.2μg/ml提高到286.8μg/ml。25、37和50℃时包合反应均能自发进行,温度较低有利于包合物的形成。
【Abstract】 The HP-β-CD inclusion compound with astragaloside Ⅳ was prepared and identified. The results showed that mean content of astragaloside Ⅳ was 20.4% in the compound and solubility at 25℃ was increased from 22.2μg/ml to 286.8μg/ml. The inclusion reaction was spontaneous at 25, 37 and 50℃. The lower temperature was preferable to the inclusion compound formation.
【关键词】 黄芪甲苷;
羟丙基-β-环糊精;
包合物;
溶解度;
制备;
【Key words】 astragaloside Ⅳ; HP-β-CD; inclusion compound; solubility; preparation;
【Key words】 astragaloside Ⅳ; HP-β-CD; inclusion compound; solubility; preparation;
- 【文献出处】 中国医药工业杂志 ,Chinese Journal of Pharmaceuticals , 编辑部邮箱 ,2007年01期
- 【分类号】R944
- 【被引频次】11
- 【下载频次】521