【摘要】 目的:观察白藜芦醇(resvaratrol,Res)对豚鼠离体心肌收缩力(contraction force,CF)和窦房结功能的影响。方法:测定Res对离体豚鼠心房肌CF和心率(heart rate,HR)影响的量效曲线,并研究不同类型钾通道阻断剂在Res对心脏负性变时变力作用的影响。结果:Res可减慢心率(P<0.05),减弱心肌CF(P<0.05);与Res组相比,ATP敏感性钾通道(KATP)阻断剂格列苯脲(Glibenclamide,Gli)、钙激活钾通道(KCa)阻断剂四乙胺(tetraethyl-ammonium,TEA)可部分阻断Res的作用(P<0.05),电压依赖性钾通道(KV)阻断剂4-氨基吡啶(4-aminopyridine,4-AP)、内向整流钾通道(KIR)阻断剂氯化钡(barium chloride,BaCl2)、乙酰胆碱(ACh)调节钾通道(KACh)阻断剂阿托品(Atropine)不能阻断Res的作用。结论:Res可呈剂量依赖性减慢HR、减弱CF,其作用是通过开放KATP及KCa有关,与K,K和K无关。更多还原

【Abstract】 Objective: To study the effects of resvaratrol derivatives on spontaneous HR and CF of isolated guinea pig atrium.Method: The dose-effect curve of resvaratrol was observed.The possible mechanism of potassium channels responsible for changes of CF and HR after administering with resvaratrol was measured.Result: Resvaratrol reduced the spontaneous HR and weakened the CF in a dose-dependent manner ranging from 10-6 to 3×10-4mol·L-1(P<0.05).As compared with Res group,the effects were partly blocked by Gli(P<0.05) and TEA(P<0.01),but not blocked by 4-AP,BaCl2,Atropine.Conclusion: Resvaratrol can induce negative chronotropic action and negative inotropic action.The mechanism(s) may relate to the opening of KATP and KCa.更多还原