【摘要】 目的:探讨局部晚期和术后复发性直肠癌三维适形放射治疗(3D-CR)的临床疗效及多肿瘤标志物的变化。方法:60例局部晚期和术后复发性直肠癌均在外照射40Gy后随机分为后程适形放疗组(适形组)30例,常规放疗组(对照组)30例。适形组放疗前后及再次复发后查多肿瘤标志物。结果:适形组及对照组有效率分别为86.7%和70.0%,两组差异无显著性意义(P>0.05)。适形组及对照组1、2、3年生存率分别为80.0%,53.3%,36.7%;56.7%,40.0%,13.3%,P=0.0213;两组差异有显著性意义。适形组CEA、CA19-9、CA242、FER在放疗后较放疗前降低,P<0.01,有显著性意义。再次复发后较未复发时升高,P<0.01,有显著性意义。结论:局部晚期和术后复发性直肠癌常规外照射加三维适形放疗有较好疗效。多肿瘤标志物蛋白质芯片诊断系统可作为疗效及预后判断的一项有效指标。更多还原

【Abstract】 Objective:To study the outcome of locally advanced or recurrent rectal cancer treated by three dimensional-conformal radiation therapy(3D-CRT)and the change of multi-tumor makers protein.Methods:60 patients with locally advanced or recurrent rectal cancer were irradiated by external beam radiotherapy to a total dose of 40 Gy,then 60 patients were divided randomly into two groups:30 cases received 3D-CRT(3D-CRT group),30 cases received conventional radiotherapy(control group).Multi-tumor makers protein of the 3D-CRT group was assessed before and after radiation therapy and after the second recurrence.Results:The overall response rates were 86.7% and 70% in the 3D-CRT group and control group,with the difference insignificant(P>0.05).Yet,for the 3D-CRT group and control group,the overall 1-,2-,3-year survival rates were 80%,53.3%,36.7%;56.7%,40%,13.3%,P=0.021 3.The contents of CEA、CA19-9、 CA242、 FER of the 3D-CRT group after radiation therapy comparing with before radiation therapy decreased significant,the difference is significant(P<0.01).Then the contents increased after the second recurrence,the the difference of the change is significant(P<0.01).Conclusion:Conventional radiotherapy plus three dimensional-conformal radiation therapy may significantly improve the effect of the treatment in locally advanced or recurrent rectal cancer.The multi-tumor makers protein diagnose system is an predictive factors of therapeutic effect and prognosis.更多还原