【摘要】 目的评价艾迪注射液联合FOLFOX-4方案治疗晚期结直肠癌的疗效与安全性。方法艾迪注射液100ml,静滴,第1~14天;CF200mg/m2,静滴2h,第1、2天;5-Fu400mg/m2,静注,第1、2天;5-Fu600mg/m2,静滴22h,第1、2天;艾恒85mg/m2,静滴2h,第1天。结果本组有效率(CR+PR)为44.8%。不良反应为恶心、呕吐,但多为Ⅰ~Ⅱ度,一过性感觉异常。结论艾迪注射液联合FOLFOX-4方案治疗晚期结直肠癌疗效较高,不良反应轻而且安全。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of AiDi injection in combination with FOLFOX-4 regimen in treatment of patients with advanced colorectal cancer.Methods AiDi injection 100 ml iv gtt d1-14,OXA 85 mg/m 2 iv gtt 2 h d1,CF 200 mg/m 2iv gtt 2 h d1-2,5-Fu 0.4 g/m 2 iv d1-2 followed by 5-Fu 0.6 g/ m 2 continuous infusion 22 hours,d1-2.Results The overall response rate (CR+PR) was 44.8%.The main side effects were nausea and vomiting of grade Ⅰ to Ⅱ,mild neuro-sensory toxicity.Conclusion AiDi injection in combination with FOLFOX-4 regimen is a highly effective regimen for advanced colorectal cancer with mild toxicity and can be used safely.更多还原