【摘要】 目的:探讨穴位注射卡介菌多糖核酸(BCG-PSN)治疗尖锐湿疣(CA)的临床疗效及免疫学机制。方法:将200例患者随机分为4组,运用激光消除疣体后,治疗组(A组)用BCG-PSN穴位注射;对照1组(B组)用BCG-PSN肌肉注射;对照2组(C组)用干扰素肌肉注射;空白对照组(D组)未行其他治疗。治疗前及治疗6个月以后检测患者细胞免疫功能,并记录其复发情况。结果:A组治愈率为94.3%,B组为78.0%,C组为80.4%,D组为78.2%,A组与其他各组比较,治愈率均高于其他各组,差异有显著性意义(P<0.05);A组的CD4+的百分率升高,CD8+的百分率降低,CD4+/CD8+比值升高,自然杀伤细胞活性升高,复发率低,与各对照组比较,差异有统计学意义(P<0.05,P<0.01)。结论:BCG-PSN穴位注射治疗效果较好,可明显降低CA复发率,细胞免疫调节作用是该疗法防止CA复发的作用机制之一。更多还原

【Abstract】 Objective To probe into immunological mechanisms and clinical therapeutic effect of acupoint-injection of BCG polysaccharide nuclear acid(BCG-PSN)for treatment of condyloma acuminatum(CA).Methods Two hundred cases were randomly divided into 4 groups.After removed the CA by laser,the treatment group(group A)was treated with acupoint-injection of BCG-PSN,the control group I(group B)with intramuscular injection of BCG-PSN,the control group Ⅱ(group C)with intramuscular injection of interferon,and the blank control group(group D)with no treatment.The levels of cellular immune function were detected before treatment and after treatment of 6 months,and the cases of relapse were recorded.Results The cured rate of 94.3% in the group A was significantly higher than 78.0% in the group B,80.4% in the group C and 78.2% in the group D,with significant diffe-rences(P<0.05);in the group A,CD+4 percent increased,CD+8 percent decreased,CD+4/CD+8 ratio increased,and NK cell activity increased with a low relapse rate,and with significant differences as compared with the control groups(P<0.05,P<0.01).Conclusion Acupoint-injection of BCG-PSN has a better therapeutic effect and it can obviously reduce the recurrence rate of CA.The cellular immunoregulatory action is one of the mechanisms of this therapy in preventing relapse of CA.更多还原