【摘要】 目的:通过探讨机械刺激对大鼠“足三里”穴筋膜组织成纤维细胞的压力信号生物转换作用,为腧穴“感受刺激,防治疾病”的现代医学生物学机制提供理论与实验依据。方法:体外培养大鼠“足三里”穴及穴旁区域的筋膜组织细胞,对细胞进行形态学鉴定后,实施压力刺激并检测细胞外培养液中前列腺素E2(PGE2)和白细胞介素-6(IL-6)含量的变化。结果:“足三里”穴及穴旁区域的筋膜组织细胞主要都是成纤维细胞,压力刺激均能够促进细胞PGE2和IL-6合成释放的增加,差异有统计学意义。结论:腧穴与非穴的筋膜组织成纤维细胞皆能直接感受刺激,从而将机械信号转换为生物信号。更多还原

【Abstract】 Objective To provide some possible theoretical and experimental basis for the modern biomedical mechanism of “receiving stimulation, preventing and treating diseases”, by exploring the effects of pressure signal’s biological transformation of rat “Zusanli” （ST 36） fascia tissue fibroblasts under mechanical stimulation. Methods Pressure was given on rat “Zusanli” （ST 36） and its adjacent area’s fascia tissue cells cultured in vitro and identified by morphology. The contents of prostaglandin E₂ （PGE₂） and interleukin-6 （IL-6） in culture medium were detected. Results The fascia tissue cells in “Zusanli” and its adjacent area are almost consisted of fibroblasts. The pressure stimulation significantly accelerated the synthesis and release of PGE₂ and IL-6. Conclusion Acupoint and non-acupoint fibroblasts can directly receive mechanical stimulation, and then the mechanical signals were transformed as biological ones.更多还原