【摘要】 目的探讨度米芬渗透泵片在额面部火器伤软组织损伤的抗菌作用。方法10只犬采用钢珠弹致伤额面部,度米芬渗透泵片植入伤口,高效液相色谱法测定软组织伤后各时间点的药物浓度,观察用药前后损伤组织的病理改变,并截取用药前后不同时间组织做需氧及厌氧培养。结果度米芬渗透泵片在组织内药物浓度高,伤后24h内放置度米芬渗透泵片的额面伤组织继发损伤轻,无明显感染。未用药的伤口组织近伤道0.8cm内严重坏死,伤口24h周围组织炎性反应明显,坏死呈进行性加重,且6h开始出现细菌感染。随时间的延长,感染的细菌明显增多,以需氧菌为主。结论度米芬渗透泵片是额面部火器伤软组织感染预防用药的有效方法之一。更多还原

【Abstract】 OBJECTIVE To evaluate the antibacterial effect of domifen osmotic pump tablet on firearm in wounds of maxillofacial soft tissue.METHODS Ten dogs were used.The maxiollofacial regions of the dogs were injuried by a steel sphere.The domifen osmotic pump tablet was placed in wound.The concentration of domifen in soft tissue were assayed by high performance liquid chromatograph (HPLC).The pathological features in the treated wound were observed before and after administration.Aerobe and anaerobe bacteria at wound track edge at different time were incubated.RESULTS Drug concentration in wound remained at high level for 24 h.The secondary injury and number of bacteria immersed in firearm wound tissue,where the domifen osmotic pump tablet was observed,was reduced at 24 h.The tissues without domifen treatment were necrotic at 0～0.8 cm distance with the inflammation of tissue.The range of necrosis became wider and wider.The quantity of infection bacteria obviously increased as the wound time was prolonged within 24 h.Aerobe bacteria in the tissue were major.CONCLUSION Domifen osmotic tablet is one of effective way in preventive medication for the infect of maxillofacial soft tissue.更多还原