【摘要】 目的考察15种药物在3种不同材质输液容器(PVC输液袋、M312C非PVC输液袋、玻璃输液瓶)中的吸着性。方法将15种药品溶于上述3种不同材质容器的输液中,分别于混匀后的0,1,3,24,48h取样,采用高效液相色谱法测定药物浓度。结果当药物于输液中混合48h后,其中药物的含量与0h相比:①在PVC输液袋中,胺碘酮、氯丙嗪和表柔比星的含量下降至76·76%89·84%之间;②在M312C非PVC输液袋及玻璃输液瓶中,除在水溶液中不稳定的药物外,其他药物含量的下降均小于10%。结论PVC输液袋会对一些药物有吸着,临床应避免这些药物在PVC输液袋中使用。更多还原

【Abstract】 OBJECTIVE To investigate the losses of fifteen injectable drugs from aqueous solutions stored in M312C Non-PVC infusion bags (NPVC), glass bottles (G) and PVC infusion bags (PVC) respectively for 48 h and compare their sorption characteristics.METHODS Each drug was separately added to above infusion bags or bottles . Samples of drug solutions were collected at 0,1,3,24,48 h and analyzed by HPLC methods.RESULTS The remaining contents of Amiodarone, Chlorpromazine, Epirubicin in PVC at 48 h were between 76.76% and 89.84%, respectively. No significant adsorption of the other drugs to the surface of G or NPVC was found (loss <10% respectively) . Cefuroxime and ceftazidime were not stable in aqueous solutions. CONCLUSION PVC should be avoided, because of its sorption of some drugs.更多还原