【摘要】 目的研究氟苯尼考的合成工艺。方法以(1R,2R)-3-羟基-2-氨基-3-[4-(甲砜基)苯基]-丙酸乙酯为原料,经过还原、保护、氟化、水解、二氯乙酰化5步反应最后得到氟苯尼考。结果与结论该合成路线简单,原料易得,目标化合物的总收率为78%。更多还原

【Abstract】 Aim To improve a synthetic route of florfenicol.Methods The target compound was synthesized by using(1R,2R)-3-hydroxy-2-amino3-[4-(methylsulfonyl)-phenyl]-ethyl propionate as starting material,via a five steps process including reduction,protection,fluorination,hydrolyzation,dichloroacetylation.Results and conclusion The starting materials in the synthetic route are easily available and the total yield is 78%.The synthetic procedure of intermediates 3-6 were improved.更多还原