【摘要】 目的:评价妥泰与丙戊酸钠对癫痫患者认知功能的影响。方法:将88例癫痫患者随机均分为妥泰组(治疗组)与丙戊酸钠组(对照组),利用简易精神状态检查量表(MMSE)、事件相关电位P300,分别于治疗前、用药4wk、用药8wk及用药6mo后对患者认知功能进行神经心理学和电生理学评估。结果:治疗组在用药4wk及8wk时与用药前比较,MMSE分值明显下降,P3潜伏期明显延长(P<0·01),而治疗前和用药6mo时各项指标比较无差异;对照组仅在用药8wk时MMSE分值明显下降,P3潜伏期明显延长(P<0·01)。结论:妥泰及丙戊酸钠均可引起癫痫患者认知功能障碍,认知功能障碍多发生于加量期,这种药物引起的认知功能障碍具有可逆性。更多还原

【Abstract】 OBJECTIVE:To evaluate the effects of topiramate and sodium valproate on cognitive function in epileptic patie-nts.METHODS:A total of 88 epileptic patients were randomly assigned to receive topiramate(treatment group) or sodium valproate(control group).To test the cognitive function,neuropsychological and electrophysiological evaluation was performed before treatment,at 4,8 weeks and 6 months after medication using Mini-Mental State Examination(MMSE) and event related potential P300.RESULTS:As compared with before treatment,at 4 and 8 weeks after medication,the treatment group showed a significantly decreased total MMSE score and significantly prolonged P3 latency(P<0.01) ;while there were no significant difference at 6 months after treatment as compared with before treatment.Only at 8 weeks after medication,the total MMSE score in control group was decreased significantly and P3 latency was significantly prolonged(P<0.01).CONCLUSI-ON:Both topiramate and sodium valproate can cause cognitive function disorder in epileptic patients,and the disorder more often occur during increasing dose period.This drug-induced cognitive function disorder is characterized by reversibility.更多还原