【摘要】 目的:制备黄芩苷分散片并建立其质量控制方法。方法:以崩解时间为指标,采用正交设计试验对黄芩苷分散片的处方进行优化,并采用HPLC法测定其含量和溶出度。结果:优化处方为交联聚维酮40%、羧甲基淀粉钠6%和预胶化淀粉2%;按优化处方制备的黄芩苷分散片在3min内完全崩解,15min溶出度达到90%以上。结论:本制备工艺简单、可行;所制分散片崩解迅速、溶出度高。更多还原

【Abstract】 OBJECTIVE: To prepare Baicalin dispersible tablets and establish a quality control method for this preparation. METHODS: The formula of Baicalin dispersible tablets was optimized by orthogonal experiment with disintegrating time as index. The content and dissolution rate of the tablets were determined by HPLC. RESULTS: The optimized formula was as follows: the contents of crospovidone, sodium starch glycolate and amylum pregelatinisatum were 40%, 6% and 2%, respectively. The dispersible tablets prepared in accordance with the optimize formula could disintegrate completely within 3 minutes and its dissolution rate could reach beyond 90% in 15 minutes. CONCLUSION: The preparation process is simple and feasible, and the prepared Baicalin dispersible tablets had a rapid disintegration and high dissolution rate.更多还原