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复方甘草酸苷注射液联合前列地尔治疗病毒性肝炎重度淤胆的临床观察

Clinical Observation on Compound Glycyrrhizin Injection Combined with Alprostadil Injection for Severe Cholestatic Virus Hepatitis

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【作者】 于桂琴秦宏林佩纯周小辉

【Author】 YU Guiqin,QIN Hong,LIN Peichun,ZHOU Xiaohui(The Second Affiliated Hospital of Medical College of Shantou University,Shantou 515041,China)

【机构】 汕头大学医学院第二附属医院汕头大学医学院第二附属医院 汕头市515041汕头市515041

【摘要】 目的:探讨复方甘草酸苷注射液联合前列地尔治疗病毒性肝炎重度淤胆的疗效。方法:采用随机对照、单盲的方法进行前瞻性试验。70例病毒性肝炎合并重度淤胆患者随机分为治疗组与对照组,2组均用复方甘草酸苷注射液治疗,治疗组加用前列地尔,疗程4wk。结果:治疗组总有效率为83%,显著优于对照组的60%(P<0·05),治疗组TBIL、DBIL、ALT、AST、GGT、PTA的下降幅度,与对照组比较有显著性差异(P<0·01)。结论:复方甘草酸苷注射液联合前列地尔可有效治疗病毒性肝炎合并重度淤胆。

【Abstract】 OBJECTIVE:To investigate the therapeutic efficacy of compound glycyrrhizin injection combined with alprostadil injection in the treatment of severe cholestatic virus hepatitis.METHODS:The study was a randomized,single-blind,controlled prospective trial.In which 70 patients with severe cholestatic virus hepatitis were randomly assigned to receive glycyrrhizin injection plus alprostadil(trial group) or glycyrrhizin injection alone(control group) for 4 weeks,with serum levels of TBIL,DBIL,ALT,AST,GGT and PTA in two groups compared after treatment.RESULTS:The total effective rate in trial group was 83%,significantly higher than in control group(60%)(P<0.05).The statistical analysis revealed that the decreasing extent in biochemical parameters for the trial group had significant differences compared with control group(P<0.01).CONC-LUSION:Compound glycyrrhizin injection combined with alprostadil injection is effective in the treatment of severe cholestatic virus hepatitis.

  • 【分类号】R512.6
  • 【被引频次】3
  • 【下载频次】73
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