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一阶导数光谱法测定奥硝唑凝胶中主药的含量
Determination of Ornidazole Gel by First Order Derivative Spectrophotometry
【摘要】 目的:建立测定奥硝唑凝胶中主药含量的方法。方法:采用一阶导数光谱法,在259nm和299nm波长处测定凝胶中奥硝唑的含量。结果:奥硝唑线性范围为4.01~44.1μg.mL-1,平均回收率为101.6%(RSD=1.3%)。结论:本方法精密度、准确度均能满足奥硝唑凝胶质量控制要求。
【Abstract】 OBJECTIVE:To establish a method for determining the content of Ornidazole gel by first-order derivative spectrophotometry.METHODS:The first-order derivative spectrophotometry was used to determine the content of Ornidazole gel at a wavelength of 259nm and 299nm.RESULTS:The linear range of Ornidazole was 4.01~44.1μg·mL-1.The average recovery was 101.6%,with RSD of 1.3%.CONCLUSIONS:This method can meet the requirements for quality control of Ornidazole gel both in terms of precision and accuracy.
【关键词】 奥硝唑凝胶;
一阶导数光谱法;
含量测定;
【Key words】 Ornidazole gel; First order derivative spectrophotometry; Content determination;
【Key words】 Ornidazole gel; First order derivative spectrophotometry; Content determination;
- 【文献出处】 中国药房 ,China Pharmacy , 编辑部邮箱 ,2007年10期
- 【分类号】R927
- 【被引频次】2
- 【下载频次】49