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一阶导数光谱法测定奥硝唑凝胶中主药的含量

Determination of Ornidazole Gel by First Order Derivative Spectrophotometry

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【作者】 吕红彭彦林怡晋园

【Author】 LU Hong,PENG Yan,LIN Yi,JIN Yuan(School of Pharmacy,Tongji Medical College of Huazhong University of Science & Technology,Wuhan 430030,China)LU Hong(Dept.of Pharmacy,Xiangfan Hospital of Dongfeng Automobile Co.,Xiangfan 441004,China)

【机构】 华中科技大学同济医学院药学院华中科技大学同济医学院药学院 武汉市430030东风汽车公司襄樊医院药剂科襄樊市441004武汉市430030

【摘要】 目的:建立测定奥硝唑凝胶中主药含量的方法。方法:采用一阶导数光谱法,在259nm和299nm波长处测定凝胶中奥硝唑的含量。结果:奥硝唑线性范围为4.01~44.1μg.mL-1,平均回收率为101.6%(RSD=1.3%)。结论:本方法精密度、准确度均能满足奥硝唑凝胶质量控制要求。

【Abstract】 OBJECTIVE:To establish a method for determining the content of Ornidazole gel by first-order derivative spectrophotometry.METHODS:The first-order derivative spectrophotometry was used to determine the content of Ornidazole gel at a wavelength of 259nm and 299nm.RESULTS:The linear range of Ornidazole was 4.01~44.1μg·mL-1.The average recovery was 101.6%,with RSD of 1.3%.CONCLUSIONS:This method can meet the requirements for quality control of Ornidazole gel both in terms of precision and accuracy.

  • 【分类号】R927
  • 【被引频次】2
  • 【下载频次】49
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