【摘要】 目的:观察川芎嗪联合促肝细胞生长素治疗慢性乙型病毒性肝炎肝纤维化的临床疗效。方法:将169例伴血清肝纤维化指标异常的慢性乙型病毒性肝炎患者随机分为治疗组与对照组,前者给予川芎嗪联合促肝细胞生长素治疗,后者给予复方丹参治疗,2组疗程均为3mo。结果:与治疗前比较,治疗组治疗后血清肝纤维化指标明显下降(P<0.01);与对照组治疗后比较,有非常显著性差异(P<0.01)。治疗组与对照组总有效率分别为87.64%、70.00%(P<0.05);半年随访,治疗组与对照组总有效率分别为81.54%、67.44%(P<0.05)。结论:川芎嗪联合促肝细胞生长素有较好的抗肝纤维化和改善肝功能作用。更多还原

【Abstract】 OBJECTIVE: To observe the therapeutic effects of ligustrazine hydrochloride used in combination with hepatocyte growth-promoting factor(PHGF) in treating chronic hepatitis B with hepatic fibrosis.METHODS: 169 cases of chronic hepatitis B with hepatic fibrosis were randomly divided into two groups: treatment group and control group.The treatment group was treated with ligustrazine and PHGF while the control group was treated only with compound danshen,each for a treatment course of three months.RESULTS: In the treatment group the serologic parameters of hepatic fibrosis declined significantly after treatment(P<0.01).There were significant differences compared with the control group(P<0.01).The overall efficacy rates in the treatment group and the control group were 87.64% and 70.00%(P<0.05) respectively.At the end of six months without treatment,the overall efficacy rates in the two groups were 81.54% and 67.44%(P<0.05) respectively.CONCLUSION: Ligustrazine combined with PHGF could resist hepatic fibrosis and obviously improve the hepatic function in chronic type B hepatitis patients.更多还原