【摘要】 目的:制备盐酸伐昔洛韦栓并建立其质量控制方法。方法:以明胶等为基质制备栓剂;采用高效液相色谱法测定盐酸伐昔洛韦的含量,并考察其稳定性。结果:所制栓剂软硬度合适;盐酸伐昔洛韦检测浓度线性范围为10.1～50.5μg·mL-1(r=0.9998),平均回收率为98.73%(RSD=0.76%,n=3)。结论:该处方制备工艺简单,制剂质量稳定、可控。更多还原

【Abstract】 OBJECTIVE: To prepare the valaciclovir hydrochloride suppository and to establish a quality control method. METHODS: The proper base material was gelatin. The valaciclovir hydrochloride was determined by HPLC and the stability test was performed. RESULTS: The prepared suppository had a proper hardness. There was a good linearity of calibration curve of valaciclovir hydrochloride in rang of 10.1～50.5μg·mL-1(r=0.999 8). The average recovery was 98.73%(RSD=0.76%,n=3).The suppository was stable. CONCLUSION: This method was simple, and the formulation thus prepared was stable and controllable in quality.更多还原