【摘要】 目的:观察六味地黄复方提取物对肾阴虚模型小鼠的药理作用,并筛选出最佳提取工艺。方法:用甲状腺素和利血平建立肾阴虚小鼠模型,并用不同提取工艺所得六味地黄复方提取物进行研究。结果:各六味地黄复方提取物对肾阴虚模型小鼠均有增加体重、自发活动次数以及增强抗疲劳、耐低温能力;最佳提取工艺采用60%乙醇超声提取。结论:六味地黄复方提取物对肾阴虚模型小鼠具有明显的改善作用;60%乙醇超声提取法的工艺条件合理可行,可为六味地黄丸复方制剂工艺改革提供依据。更多还原

【Abstract】 OBJECTIVE: To observe the pharmacological actions of extract of six-Ingredient rehmannia compound on kidney-yin-vacuity mice and to select the optimum exracting technique. METHODS: The kidney-yin-vacuity models of mice were made with thyroxine and reserpine, and then were treated with the extracts of six-Ingredient rehmannia compound. RESULTS: The extracts of six-ingredient rehmannia compound can increase the body weight and spontaneous locomotor activities, and enhance the abilities of anti-fatigue and anti-low temperature in kidney-yin-vacuity mice, and the optimum extracting technique is supersonic extraction with 60% ethanol. CONCLUSIONS: The six-ingredient rehmannia compound possesses marked beneficial actions on kidney-yin-vacuity mice. The result from supersonic extraction method with 60% ethanol is so stable and reliable that it can provide a basis for the improvement of technologic process of compound preparation of six-ingredient rehmannia compound.更多还原