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利福平栓剂的制备及其体外溶出度测定
Preparation of Rifampicin Suppositories and Solubility Determination
【摘要】 目的:制备利福平栓剂并测定其体外溶出度。方法:以明胶及甘油等为基质制备利福平栓剂;采用紫外分光光度法测定利福平栓剂的溶出度,并与市售利福平胶囊比较。结果:利福平检测浓度在10.0~60.0μg.mL-1范围内线性关系良好(r=0.9999),平均回收率为99.87%(RSD=0.42%,n=6)。利福平栓剂及胶囊45min时体外溶出度分别为(89.9±0.97)%、(79.8±1.14)%。结论:该制剂制备方法简单,成模性好,成本低,体外溶出度较高。
【Abstract】 OBJECTIVE: To prepare rifampicin suppositories and to determine its dissolution in vitro. METHODS: Rifampicin suppositories were prepared with gelatin and glycerine as base material, the dissolution of rifampicin suppositories was determined by UV spectrophotometry and which were compared with rifampicin capsules sold in the market. RESULTS: The linear range of rifampicin was 10.0~60.0μg·mL-1(r=0.9 999), and the average recovery was 99.87%(RSD=0.42%, n=6). The dissolutions of rifampicin suppositories and rifampicin capsules in vitro at 45min were(89.9±0.97)% and(79.8±1.14)%, respectively. CONCLUSION: Rifampicin suppositories were simple in preparative method, well-formed, low in cost, and with high dissolution in vitro.
- 【文献出处】 中国药房 ,China Pharmacy , 编辑部邮箱 ,2007年01期
- 【分类号】R927.2
- 【被引频次】5
- 【下载频次】436