【摘要】 目的观察聚维酮碘腹腔冲洗留置预防和控制术后肠粘连和腹腔感染的效果。方法以小鼠作为动物模型,建立实验性腹腔粘连、急性化学性和化脓性腹膜炎,对聚维酮碘预防和控制效果进行观察。结果含有效碘250~500mg/L聚维酮碘溶液腹腔冲洗留置对肠粘连率、粘连程度及平均粘连长度均有降低,但与对照组比较无统计学差异。含有效碘500mg/L的聚维酮碘溶液腹腔留置可显著降低小鼠腹腔毛细血管通透性,对醋酸所致小鼠急性化学性腹膜炎有一定的保护作用。用含有效碘250~500mg/L的聚维酮碘溶液腹腔留置,可显著抑制实验动物腹腔脓肿和腹腔粘连率,降低动物死亡率。结论聚维酮碘溶液腹腔冲洗留置,可降低腹腔粘连程度、粘连长度和粘连率;降低小鼠腹腔毛细血管通透性;减轻腹腔脓肿和粘连,降低试验动物死亡率,具有一定预防和控制术后肠粘连和腹腔感染的作用。更多还原

【Abstract】 Objective To observe the efficacy of abdominal rinse with and retention of povidone-iodine in prevention and control of postoperative intestinal adhesion and abdominal infection. Methods Mice were used as the animal model and experimental abdominal adhesion, acute chemical and purulent peritonitis were established to observe the preventive and controlling efficacy of povidone-iodine. Results Abdominal rinse with and retention of povidone-iodine solution containing available iodine 250-500 mg/L reduced intestinal adhesion rate, degree of adhesion and average adhesion length, however, no statistical difference compared with the control group. Abdominal retention of povidone-iodine solution containing available iodine 500 mg/L could reduce significantly the permeability of abdominal capillaries in mice and presented certain protective effect against acute chemical peritonitis induced by acetic acid in mice. Abdominal retention of povidone-iodine solution containing available iodine 250-500 mg/L could inhibit obviously abdominal abscess and abdominal adhesion in experimental animals and reduce mortality of the animals. Conclusion Abdominal rinse with and retention of povidone-iodine solution can reduce the degree of abdominal adhesion, adhesion length and adhesion rate, reduce the permeability of abdominal capillaries in mice, alleviate abdominal abscess and adhesion and reduce mortality of experimental animals, so it has certain efficacy in prevention and control of postoperative intestinal adhesion and abdominal infection.更多还原