【摘要】 目的探讨估计日本血吸虫感染两种检测方法(ELISA和Kato-Katz)在现场应用时的灵敏度和特异度的新方法。方法采用贝叶斯(Bayes)统计方法,利用2005年云南省洱源县现场调查资料,对两种方法在流行区和非流行区应用时的检测效果分别进行了评价。结果在流行区,ELISA灵敏度较高(0.913,中位数,下同)而特异度较低(0.584),Kato-Katz法灵敏度低(0.148)而特异度很高(0.994);在非流行区,ELISA灵敏度为0.766,特异度为0.908,Kato-Katz法灵敏度和特异度与其在流行区的相似。结论在无金标准的情况下,Bayes方法能够对检测方法做出科学的评价。更多还原

【Abstract】 Objective To explore a novel approach to estimate the sensitivities and specificities of two tests,i.e.,ELISA and Kato-Katz,for detecting schistosoma japonicum infection when used in the field.Methods A Bayesian approach was employed to evaluate the characteristics of the two tests when used in endemic and non-endemic areas,respectively,based on the data from the field investigation in Eryuan county of Yunnan province,2005.Results In endemic areas,a high sensitivity with the median of 0.913 and a low specificity with the median of 0.584 preserited in ELISA,and a low sensitivity with the median of 0.148 along with a very high specificity(0.994)appeared in Kato-Katz.In non-endemic areas,a moderate sensitivity of 0.766 with a high specmcity(0.908)was showed in ELISA,and the sensitivity and specificity of Kato-Katz was similar to that in endemic areas,respectively.Conclusion The Bayesian approach can evaluate the test pmpenies appropriately when there is no go1d standard.更多还原