【摘要】 目的:观察橄榄桥脑小脑萎缩(OPCA)脑干听觉诱发电位各波、波间潜伏期的变化,并分析这些变化与桥脑体积/后颅窝体积比值(PV/PFV)的相关性。方法:利用丹麦KeypointEMG/EP电生理仪测定OPCA组、对照组脑干听觉诱发电位Ⅰ、Ⅲ、Ⅴ波潜伏期(PL),Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ峰间潜伏期(IPL)并采用1.5TMR3DVolumeRender-ing软件行桥脑体积(PV)、小脑体积(CV)、后颅窝体积(PFV)磁共振测量,算出PV/PFV、CV/PFV、PV/CV值。结果:与对照组相比,OPCA组Ⅲ波PL、Ⅰ-ⅢIPL明显延长(P<0.05),Ⅲ-ⅤIPL明显缩短(P<0.05);OPCA组PV/PFV值明显减少(P<0.01);Ⅲ-ⅤIPL与PV/PFV呈正相关(r=0.83,P<0.01)。结论:OPCA患者脑干听觉诱发电位Ⅲ波PL、Ⅰ-ⅢIPL延长,Ⅲ-ⅤIPL缩短,Ⅲ-ⅤIPL随着桥脑体积的变小而缩短。更多还原

【Abstract】 Aim:To investigate the change of latency and interpeak latency of each component of BAEP(brainstem auditory evoked potential,BAEP)and its correlation with PV/PFV(pontine volume/posterior fossa volume,PV/PFV)ratio in OPCA(olivopontocerebellar atrophy,OPCA).Methods:We used Keypoint EMG/EP to determine wavesⅠPL(peak latency,PL),Ⅲ PL,Ⅴ PL and Ⅰ-Ⅲ IPL(interpeak latency,IPL),Ⅲ-Ⅴ IPL,Ⅰ-Ⅴ IPL and used 1.5TMR 3D volume rendering software to determine PV(pontine volume,PV),CV(cerebellar volume,CV)and PFV(posterior fossa volume,PFV).Then calculated PV/PFV ratio,CV/PFV ratio and PV/CV ratio in OPCA group and control group.Results:Compared with control group,in OPCA group wave Ⅲ PL,Ⅰ-Ⅲ IPL were significantly elongated(P<0.05),Ⅲ-ⅤIPL was significantly shorten(P<0.05),PV/PFV ratio was significantly decreased(P<0.01);there was a positive correlation between Ⅲ-ⅤIPL and PV/PFV ratio(r=0.83,P<0.01).Conclusion:In patients with OPCA,Ⅲ PL,Ⅰ-Ⅲ IPL of BAEP were elongated and Ⅲ-ⅤIPL of BAEP was shorten.Ⅲ-Ⅴ IPL became shorter when the volume of pontine decreased.更多还原