【摘要】 目的研究老年人认知功能障碍与颈动脉粥样硬化斑块的相关性,探讨认知功能障碍的发生、发展及预后,为该类疾病的干预和治疗提供参考。方法采用病例-对照研究方法,选取开滦集团公司离退休职工体检中检出的认知功能障碍者258例作为病例组,选取同期在开滦医疗集团健康查体者,年龄、性别与病例组相匹配的非认知功能障碍708例为对照组。采用美国ATLHDI—超9彩色多普勒超声仪,确定颈动脉斑块的形态、大小。结果有颈动脉粥样硬化斑块者患认知功能障碍的占30.2%,明显高于无颈动脉粥样硬化斑块者的21.6%,有颈动脉粥样硬化斑块患认知功能障碍的风险增加了1.58倍(95%CI 1.17~2.13),颈动脉粥样硬化斑块级别与认知功能障碍之间存在一定的剂量反应关系,级别越高OR值越大。结论颈动脉粥样硬化斑块与认知功能障碍具有相关性,是认知功能障碍的独立危险因素。颈动脉粥样硬化斑块级别越高,患认知功能障碍的危险越大。更多还原

【Abstract】 Objective To study the effect of the carotid atheromatous plaque on cognitive impairment in elderly patients and explore the happen,development and prognosis of cognitive impairment,it was helpful to provide theoretical basis of intervention therapy for the disease.Methods A case-control study was carried out.258 cognitive impairment patients from Kailuan hospital were diagnosed by physical examination as case group;708 healthy subjects were selected as control group,the age and sex of two groups were matched.The morphology and size were examined by color Doppler sonography-9 made in America.Results Cognitive impairment patients with carotid atheromatous plaque were significantly higher than those who hadn’t carotid atheromatous plaque(30.2% vs 21.6%).The grade of carotid atheromatous plaque was related to cognitive impairment,the change of OR was following the grade.Conclusion The carotid atheromatous plaque was related to cognitive impairment.It was a unique risk faster of cognitive impairment.With the grade of carotid atheromatous plaque rising,the risk of cognitive impairment become more and more higher.更多还原