【摘要】 目的经鼻持续气道正压通气(nCPAP)治疗高血压合并阻塞性睡眠呼吸暂停低通气综合征(OS-AHS)患者,以评价该疗法对血压和睡眠呼吸监测参数的影响。方法临床确诊合并OSAHS的高血压患者,随机分为治疗组和对照组,治疗组在给予常规药物(抗高血压药、抗动脉硬化药物)治疗的同时进行nCPAP治疗,对照组仅给予常规药物治疗。30天后,观察两组治疗前后血压、睡眠呼吸监测参数变化。结果高血压合并OSAHS患者共60例,治疗组和对照组各30例;治疗后治疗组的收缩压(SBP)、舒张压(DBP)、脉压(PP)、心率(HR)、睡眠呼吸暂停低通气指数(AHI)、最长呼吸暂停时间和最低脉搏容积血氧饱和度(SpO2min),与对照组比较差异有统计学意义(P<0.05);部分患者降压药物减量或停用,仅用nCPAP治疗就能维持正常血压。结论nCPAP是非药物治疗合并OSAHS高血压患者的一种安全有效方法。更多还原

【Abstract】 Objective To evaluate the efficacy of nasal continuous positive airway pressure (nCPAP) on the blood pressure and the parameters of sleep respiration in patients of hypertension complicated with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods Sixty cases of hypertension complicated with OSAHS were randomly divided into treatment group n=30 and control group n=30. nCPAP and routine drug treatment (antihypertensive and anti-atherosclerosis medications) were administered in the treatment group, while only routine drug treatment was given in the control group. Blood pressure and parameters of sleep respiration in two groups were compared before and after treatment. Results SBP, DBP, pulse pressure, heart rate, apnea hypopnea index (AHI), maximum apnea duration, and minimum pulse oxygen saturation (SpO_ 2 min ) were significantly improved (P<0.05) after nCPAP treatment. The antihypertensive medications were decreased or even discontinued in some patients, in whom only nCPAP was able to keep the normal BP. Conclusion nCPAP was a safe, effective treatment in hypertension complicated with OSAHS.更多还原