【摘要】 目的探讨宫内节育器(IUD)使用与子宫内膜癌的关系。方法采用病例对照研究方法,调查上海市区1997年1月～2000年12月间确诊、年龄在30～69岁之间的子宫内膜癌患者(n=1204)和普通对照人群(n=1212)的一般情况、月经生育史、饮食、个人生活习惯、口服避孕药(OC)及宫内节育器使用情况、疾病及家族史等。采用非条件Logistic回归模型分析宫内节育器使用与子宫内膜癌的关系。结果上海市区女性所使用的宫内节育器类型主要为金属环和V型塑料环,分别占使用者的68.1%和20.7%。与从未使用过宫内节育器的女性比较,使用者发生子宫内膜癌的危险性显著降低。调整后OR=0.57(95%CI=0.47～0.69),且随使用时间增加而降低。分层分析显示,在从未服用口服避孕药的女性中,曾使用IUD者发生子宫内膜癌的危险降低,OR=0.51(95%CI=0.41～0.64)。结论绝经前后女性使用宫内节育器可能会降低子宫内膜癌的风险。更多还原

【Abstract】 Objective To evaluate the inter uterine device(IUD)use with risk of endometrial cancer.Methods In a population based case-comtrol study was conducted in urban Shanghai.In-person interviews were completed for 1 204 incidence cases aged 30～69 from January 1997 to December 2002,and 1 212 controls frequency-matched were selected to cases on age.Unconditional Logistic regression model was applied to drive odds ratios and confidence interval in association with IUD use.Results The most frequently used IUD in Shanghai were metallic and V-shaped plastic IUD(68.1% and 20.7%).A significant inverse association was observed for IUD use and endometrial cancer risk.Compared to nonusers,women with a history of IUD use had a significant reduced risk of endometrial cancer(OR=0.57;95%CI:0.47～0.69)and the ORs decreased with the increase of using years.The inverse association did not appear to be modified by menopausal status and oral contraceptive use.Conclusion IUD use is inversely associated with endometrial cancer risk among women in urban shanghai.更多还原