【摘要】 目的分析超重、肥胖男青少年血清脂联素水平与肝转氨酶活性的关系,探讨脂联素对肝脏脂代谢异常疾病的影响。方法随机抽选132名14~16岁超重、肥胖男中学生,测量身高、体重和血压,检测血脂、血清脂联素、胰岛素和转氨酶水平。结果转氨酶增高组与正常组体质指数(BMI)、腰围(WAIST)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、胰岛素抵抗指数(HOMA-IR)和脂联素水平差异有统计学意义(P<0.05)。脂联素与转氨酶(ALT)对数呈显著负相关(r=-0.209,P<0.05),校正BMI、WAIST后相关性差异无统计学意义。结论低脂联素血症可引发与脂代谢异常有关的肝脏疾病;这一损害受体成分和脂肪分布的影响。更多还原

【Abstract】 Objective To study the association between serum adiponectin and transaminase acitivities in male adolescents,and discuss the impact of adiponectin on fatty liver.Methods 132 male adolescents aged 14～16 were randomly selected,and their body weight,height and blood pressures were measured.Blood samples were collected from each subject after fasting for(10 h) and the levels of ALT,serum lipids,and glucose were routinely measured.Serum adiponectin and insulin levels were examined by enzyme-linked immunosorbent assay and RIA.Results Various markers of metabolic diseases including body mass index(BMI),waist,serum triglyceride,and insulin resistance assessed by the homeostasis model were significantly higher in subjects with increased transaminase activities compared to those with normal activities.Correlation analyses demonstrated that the serum adiponectin level was inversely correlated with the level of logarithmic serum ALT(r=-0.209,P<0.05).After controlling BMI and WAIST,the inverse correlation were not significant(P>0.05).Conclusion Hypoadiponectinemia may worsen liver diseases associated with metabolic diseases in adolescents,but this damage may be effected by BMI and WAIST.更多还原