【摘要】 目的:观察己酮可可碱(pentoxifylline,PTX)对高氧肺损伤新生大鼠的保护作用。方法:新生Wistar大鼠160只,随机分成空气对照组、空气+PTX组、高氧对照组、高氧+PTX治疗组。高氧组与治疗组分别建立高氧肺损伤模型,治疗组制备模型后腹腔注射PTX(20mg/kg.d)。各组模型3、7、12、15天随机分批处死,取肺组织检测SOD活力、MDA水平,并对肺组织进行HE染色观察肺发育程度。结果:高氧对照组SOD活力低于高氧+PTX治疗组,MDA水平明显高于PTX治疗组(P<0.01)。结论:PTX对新生大鼠高氧肺损伤有保护作用。更多还原

【Abstract】 Objective:To study the the potential role of pentoxifylline(PTX)to prevent neonatal rats lungs with hyperoxia damage.Methods:We had used 4 groups in the study.I:normal control group;II :normal control group+PTX;III:hyperoxia group;IV:hyperoxia group+PTXo.Hyperox lung injury was induced after high concentration oxygen inhalation.Then the rats were administrated with PTX(20mg/kg/day)by intraperitoneal(IP).The rats were killed on days 3,7,12,and 15 after the initial high concentration oxygen inhalation.And detected the lung pathophysiological features,the level of SOD,MDA in lung tissues.Results:The activity of SOD was significantly decreased in treated with PTX than hyperoxia-induced lung injury model.The increased MDA levels after hyperoxia induced lung injury were decreased by the administration of PTX.Conclusion:These findings indicate that PTX play a important role to prevent and/or treat neonatal rats lung with hyperoxia damage.更多还原