【摘要】 目的:观察普贝生用于足月引产的临床效果及其安全性。方法:将120例妊娠足月、宫颈Bishop评分≤5分、有阴道分娩适应症、无引产禁忌症的单胎头位初产妇随机分为两组:60例将普贝生一枚(10 mg)置于阴道后穹窿作为实验组,若无不良反应,12 h后取出;60例给予硫酸普拉酮钠200 mg/d静脉推注3天作为对照组。比较两组产妇用药前及用药后12 h的宫颈Bishop评分、临产情况、剖宫产率、对胎儿及新生儿的影响。结果:用药12 h后,实验组有51例宫颈评分提高≥2分,有效率为85%;而对照组末次用药12 h后有9例宫颈评分提高≥2分,有效率仅为15%。两组间有显著性差异(P<0.01);24h内实验组70%(42/60)的孕妇临产,对照组6.6%(4/60)的孕妇临产,两组间有显著性差异(P<0.01);实验组65%(39/600)的孕妇经阴道分娩,对照组41.7%(25/60)的孕妇经阴道分娩,两组间有显著性差异(P<0.05);两组间胎儿窘迫发生率、新生儿Apgar评分均无统计学差异(P>0.05)。结论:普贝生能够有效促进宫颈成熟,引产成功率高,副作用少,可以较安全用于临床。更多还原

【Abstract】 Objective:To observe the clinical effects and safety of propess used for induction of term pregnancy.Methods:120 single term pregnant women with proper fetal position,the cervical Bishop scoring≤5,without any vaginal delivery taboo were randomly divided into test group,in which one piece of propess was put into the vaginal posterior fornix for 12 hours and control group,in which the DHA-S was used intravascularly.The cervical maturity(by Bishop scoring) before this management and 12 hours after treatment,the time to labor starting,Cesarean section rate,fetal and neonatal condition were compared between two groups.Results:Bishop score of the test group was increased ≥2 points in 85% cases,whereas only 15% cases whose Bishop score increased ≥2 points in control group.The time to labor starting was shortned obviously in test group than that in control group.Cesarean section rate was reduced in the test group.There was no significant difference between two groups in fetal and neonatal condition.Conclusion:Propess has no adverse effect on the mothers and babies.It can be used for induction of term pregnancy effectively and safely.更多还原