【摘要】 目的:探讨原因不明习惯性流产(URSA)患者外周血T淋巴细胞亚群在主动免疫治疗前后的变化。`方法:用流式细胞仪测定并比较经主动免疫治疗前后的32例URSA患者外周血CD3+、CD4+、CD8+细胞亚群百分率及CD4+/CD8+比值;同时选择30例正常早孕妇女作为对照。结果:与对照组比较,URSA患者外周血中CD4+细胞百分率及CD4+/CD8+比值升高,CD8+细胞百分率降低(均P<0.01),而两组CD3+细胞百分率无差异。主动免疫治疗后CD3+细胞无变化,CD4+细胞、CD4+/CD8+比值较治疗前明显下降;CD8+细胞则明显升高(均P<0.01)。结论:CD4+细胞百分率升高、CD8+细胞百分率降低与UR-SA发生有关;主动免疫治疗可降低CD4+细胞百分率,提高CD8+细胞百分率,有利于妊娠发展。更多还原

【Abstract】 Objective:To investigate the changes of T lymphocytes sub-types in unexplained recurrent spontaneous abortion(URSA) women before and after active immunotherapy.Methods:Flow cytometry was used to measure T lymphocytes sub-types of 32 URSA women before and after active immunotherapy and 30 normal early pregnant women were taken as control.Results:Compared with control group,CD4+ cells and CD4+/CD8+ ratio increased significantly in URSA women,but CD8+ cells decreased significantly,there were no significant changes in CD3+ cells between two groups.After active immunotherapy,CD4+ cells and CD4+/CD8+ ratio dropped,but CD8+ cells increased greatly in URSA women,there were still no significant changes in CD3+ cells.Conclusion:The occurrence of URSA might be associated with proliferation of the CD4+ cells and decrease of the CD8+ cells.Markedly dropped CD4+ cells and increased CD8+ cells in URSA women after active immunotherapy is in favor of conception.更多还原