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血镉对儿童外周血TH1、TH2细胞亚群的影响研究

Analysis of the effect of blood cadmium on the condition of TH1,TH2 in the peripheral blood of the children

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【作者】 陈继红陈德珩李富荣

【Author】 CHEN Ji-Hong,CHEN De-Heng,LI Fu-Rong.Department of Children Health Care,Shenzhen People’s Hospital,Shenzhen 518000,Guangdong,China

【机构】 广东省深圳市人民医院广东省深圳市人民医院 518001518001

【摘要】 目的:研究血镉对儿童外周血TH1、TH2细胞数水平的影响。方法:采用原子吸收法测定血镉的含量,流式细胞分析方法测定TH1、TH2细胞水平。结果:血镉异常组TH1、TH2细胞水平与血镉正常组相比有显著差异(P<0.05)。结论:血镉含量增高会降低儿童外周血TH1、TH2细胞数水平。

【Abstract】 Objective:To explore the relationship between the concentration of blood cadmium and the level of TH1,TH2 cytokines in the peripheral blood of the children.Methods:The blood cadmium levels in venous blood specimens of 3 652 children were measured by performing atomic absorption spectromentry method.Flow cytometry was employed to obtain the level of TH1(IFN-γ+),TH2(IL4) in the peripheral children blood.Results:The levels IFN-γ and IL-4 between testing groups,whose blood cadmium levels were abnormal and the normal controls were significantly differently(P<0.05).Conclusion:The concentration of the blood cadmium intends to decrease the level of TH1,TH2 in the children peripheral blood.

【关键词】 儿童血液TH1TH2
【Key words】 ChildrenBloodCadmiumTH1TH2
  • 【文献出处】 中国妇幼保健 ,Maternal and Child Health Care of China , 编辑部邮箱 ,2007年08期
  • 【分类号】R179
  • 【下载频次】84
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