【摘要】 目的:探讨婴幼儿病毒性肺炎的病原学及免疫功能变化。方法:采集婴幼儿肺炎组及正常对照组外周血,用ELISA法检测RSV、IFV、ADV、PIV、CMV血清特异性IgM,速率散射比浊法检测IgG、IgA、IgM、CRP,碱性磷酸酶标记链霉卵白素(S-A/AP)法检测T淋巴细胞亚群。结果:104例婴幼儿病毒性肺炎中,单独病毒感染75例,占大部分,其中RSV21例居首位,余依次为IFV18例、ADV15例、PIV11例、CMV10例;混和病毒感染29例,分别是IFV+PIV10例、IFV+RSV6例、ADV+PIV6例、ADV+IFV5例、PIV+RSV2例。病毒性肺炎组CD3↓、CD4↓、CD4/CD8↓、CD8↑,与对照组比较有显著差异(P<0.05),而IgG、IgA、IgM与对照组无显著差异(P>0.05)。结论:病毒感染是婴幼儿肺炎的主要病原,单独病毒感染为主,混和感染为辅,病毒病原谱具有地区性差异。病毒性肺炎患儿存在细胞免疫紊乱。更多还原

【Abstract】 Objective:To explore the etiology and immunological changes of infant viral pneumonia in Luzhou area.Methods:Viral specific serum lgM antibodies of five kinds of virus (RSV、IFV、ADV、PIV、CMV)were detected by ELISA lgG、lgA、lgM and CRP were detected by rate scattered nephelometry. T lymphocyte subpopulations were detected by streptavidin-alkaline phosphates (S-A/AP)method.Results:Among 104 viral pneumonia there were75cases of single virus infection,successively they were RSV:21cases (20.1%), IFV:18 cases (17.3%), ADV:15 cases (14.4%), PIV: 11cases(10.6%), CMV:10cases(17.3%);there were 29 cases of mixed viral infection,successively they were IFV+PIV: 10 cases(9.6%), IFV+ RSV 6 caces(5.8%), ADV+PIV: 6 cases(5.8%), ADV+IFV 5 cases (4.8%), PIV+RSV:2 cases (1.9%).There were significant differences in CD3、CD4、CD4/CD8 counts(all P<0.05),there were not significant differences in immunoglobulin lgG、lgA、lgM (all>0.05)between viral group and controlled group.Conclusion:Viral infection was the main etiology,the majority was the single viral infection. The viral etiology was not equal to other area totally ,expressing the area discrepancy The immune function of viral pneumonia infant dedine,concretely expressing T lymphocyte subpopulation was disordery,CD3、CD4、CD4/CD8 all decline ,CD8 rise up ,while there was not significant change in humeral immunity.更多还原