【摘要】 目的通过研究鼻咽癌患者放射治疗前后血内源性NO浓度的变化,旨在探讨鼻咽癌放射治疗与NO的关系。方法运用硝酸还原酶法分别检测20例鼻咽癌患者放疗前及放疗结束时、放疗后1年以上者和27例健康体检者血清中NO的浓度。结果①鼻咽癌患者血清NO含量显著高于健康人(P<0.01)。②鼻咽癌放疗结束时血清NO含量比放疗前明显降低(P<0.01)。③鼻咽癌患者放疗后1年以上血清NO含量较健康者及放疗结束时高(P<0.01),而远未达到放疗前的水平(P<0.05)。结论内源性NO在分子水平上可能参与鼻咽癌的发生、发展过程,监测血清NO水平的变化,对评估鼻咽癌患者病情和预后有一定的临床价值。更多还原

【Abstract】 Objective To explore the correlation between radiotherapy and the serumal level of endogenous nitric oxide (NO) in patient with nasopharyngeal carcinoma (NPC). Methods The levels of NO were detected by nitrate reductase method in sera from 20 patients with NPC at the time points before radiotherapy, immediately after radiotherapy, and one year after radiotherapy. 27 healthy adults were taken as control; their levels of NO were also detected. Results ① The levels of NO in NPC patient before radiotherapy was significantly higher than that in of control group (P<0.01). ② The levels of NO in NPC patients immediately after radiotherapy were significantly lower that those before radiotherapy (P<0.01). ③ The levels of NO in NPC patients one year after radiotherapy were higher than those in control group and NPC patients immediately after radiotherapy (P<0.01), but much lower than those in NPC patients before radiotherapy (P<0.05). Conclusion NO may play an important role in the carcinogenesis and development of NPC at molecular level. Concentration monitoring of serumal NO maybe helpful to evaluate the state and prognosis of NPC patients.更多还原