【摘要】 目的探讨乳腺纤维瘤病的临床病理特征。方法应用常规组织病理切片和免疫组化染色来观察1例乳腺纤维瘤病,并复习相关文献。结果肿瘤由梭形细胞和胶原纤维构成。梭形细胞为增生的纤维母细胞和肌纤维母细胞,构成束状交错形态,外周指样扩展常见,局部有淋巴细胞浸润,在边缘区最明显。瘤细胞Vim和SMA(+),ER、PR、34βE12、CK5/6、CD34、S-100、CKAE1/AE3、EMA细胞标记均(-)。结论乳腺纤维瘤病为少见的乳腺良性肿瘤,由增生的纤维母细胞、肌纤维母细胞和胶原纤维共同组成。临床、钼靶和超声检查与癌难以区分,诊断主要依靠病理组织切片,在形态上应注意与乳房的其他梭形细胞病变相区别。更多还原

【Abstract】 Objective To explore the clinicopathologic features of fibromatosis of the breast. Methods A case of fibromatosis in the breast was studied with conventional histopathological sections and immunohistochemical stains and review of literatures. Results The neoplasm was composed of spindle cell and collagen fibers. The spindle cells were proliferating fibroblasts and myofibroblasts forming interlacing fascicles. At the periphery, infiltrating finger-like extension was common. The lesions had focal lymphocytic infiltration which tended to be most prominent at the margins. Tumor cells were positive for Vim and SMA protein, but negative for ER, PR, 34βE12, CK5/6, CD34, S-100, CKAE1/AE3 and EMA. Conclusion Mammary fibromatosis,a rare benign tumor of the breast, consists of proliferating fibroblasts, myofibroblasts and collagen fibers. It is usually indistinguishable from carcinoma in physical examination, mammography and ultrasound. The diagnosis mainly bases on histopathological sections. Morphologically, it should be distinguished from other spindle cell lesions in the breast.更多还原