【摘要】 目的探讨青少年阑尾类癌的临床病理特点。方法回顾性分析10例青少年阑尾类癌的临床病理资料及HE切片,并进行嗜铬颗粒蛋白A(CgA)、神经元特异性烯醇化酶(NSE)、突触素(Syn)免疫组化标记辅助诊断。结果肿块位于阑尾末端8例,根部2例。肿块直径<2 cm者8例,均行阑尾切除术;直径>2 cm者2例,1例行盲肠切除术,1例行右侧结肠切除术。光镜下癌细胞大小、形状、染色较一致,排列呈巢状、腺泡状。10例CgA、NSE均为(+),7例Syn为(+)。10例均经随访未见复发和转移。结论阑尾类癌为低度恶性的APUD源性肿瘤,预后较好。青少年患者手术治疗后可不需化疗、放疗。更多还原

【Abstract】 Objective To investigate the clinical and pathologic characteristics of appendiceal carcinoids in adolescence. Methods The clinical data and pathological changes in HE sections were analyzed in 10 adolescent patients with appendiceal carcinoid from Jan.1985 to Dec.2004 retrospectively.Immunohistochemical staining of chromogranin(CgA),neuron-specific enolase(NSE) and synaptophysin(Syn)was conducted for adjuvant diagnosis. Results Eight tumors were localized at the tip of appendix,and 2 at the base of the appendix.The tumor was less than 2?cm in diameter in 8 cases and larger than(2?cm) in 2 cases.All the small tumors underwent appendectomy while for the large tumors,one accepted cecectomy and the another underwent right hemicolectomy.Tumor cells,arranged in cluster or glandular acinus,were identical in size,shape,and color under light microscope.CgA,NSE and Syn were positive in 10,10 and 7 cases respectively.The follow-up was performed in all these patients and they all remained free of tumor recurrence and metastasis. Conclusion The appendiceal carcinoid,deriving from APUDC,is less malignant tumor with good prognosis.Neither chemotherapy nor radiotherapy is suggested to adolescent patients after surgical removal of the tumor.更多还原