【摘要】 目的研究转金属硫蛋白基因平菇对小鼠抗辐射能力的影响。方法以ICR小鼠为实验动物,将转金属硫蛋白基因平菇干粉掺入其饲料喂养,至D23以5.0Gy60Co-γ射线对小鼠全身照射一次做辐射损伤模型,继续喂养7d检测其抗辐射能力。结果转金属硫蛋白基因平菇可显著改善辐射对小鼠血小板(PLT)和脾脏的损伤;明显增强受辐射小鼠血清SOD活性,降低其血清MDA含量。结论转金属硫蛋白基因平菇能明显增强小鼠辐射后的抗氧化能力。更多还原

【Abstract】 Objective: To explore the effect of transgenic metallothionein (MT) mushroom on anti-radiation ability of mice. Method: Dried power of transgenic MT mushroom was mixed into the feed of ICR mice. After being fed for 23 d, they were irradiated by 5.0Gy 60Co-γrays. Then their anti-radiation ability was determined after being fed 7 d again. Results: Transgenic MT mushroom can evidently alleviate the injury of platelet and spleen induced by radiation, and apparently increase SOD activity and reduce MDA content in irradiated mice’s serum. Conclusion: Transgenic MT mushroom can improve anti-oxidation ability of irradiated mice.更多还原