【摘要】 目的:了解2005年某市结核病防治院住院结核病人的耐药情况,从地域分布、年龄、正规用药角度探讨产生耐多药结核病(MDR-TB)原因。方法:回顾性调查2005年收治的333例结核菌培养阳性病人地域分布、年龄分布、抗痨用药史,并对全部培养阳性菌进行菌型鉴定及药物敏感性试验。结果:初始耐药率为20.85%,城市、县镇、乡村分别为20.00%、13.89%、25.67%。获得性耐药率为85.42%,城市、县镇、乡村分别为65.52%、88.24%、96.00%。<25岁、25~50岁、>50岁年龄分布MDR-TB初始耐药例数分别为4例、4例、3例,获得性耐药例数分别为3例、17例、5例。正规与不正规用药者MDR-TB耐药率分别为19.05%、28.00%。结论:某市结核病防治院住院结核病人获得性耐药率及MDR-TB获得性耐药率在地域分布上乡村>县镇>城市,在年龄分布上25~50岁组获得性MDR-TB明显增高,不正规用药者MDR-TB获得性耐药率明显增高。应加强乡镇人口治疗管理,重视对初治病人的结核菌培养及药敏试验。更多还原

【Abstract】 Objective: To investigate resistant situation to anti-TB drugs among in-patients in A Anti-TB Hospital in 2005 and the reason of drugs resistance among patients from year、area、standard treatment.Methods:Analysis was conducted on laboratory data concerning mycobacterial type identification test and drug susceptibility test.Results:The total initial drug resistance rate was 20.00%、13.89%、25.67%,the total acquired drug resistance rate was 65.52%、88.24%、96.00%respectively for patients from cites、towns、rural area.Conclusion: Resistance to Anti-TB drugs was the highest among rural in-patients of the hospital.In order to control TB,must improve the detection and management for TB in rural and towns population.更多还原