【摘要】 心肌缺血再灌注(MIR)会导致冠状动脉内皮损伤。神经肽Y(NPY)具有收缩冠状动脉、损伤血管内皮和兴奋交感神经等作用,参与了冠心病的发病过程和MIR损伤,也反映了冠心病的病情。NPY可能通过损伤冠状动脉内皮功能、脂质过氧化反应和降低心肌细胞清除氧自由基的能力而导致MIR损伤。更多还原

【Abstract】 Myocardial ischemical reperfusion can impair coronary artery endothelium.NPY has the function of shrinking coronary artery,impairing blood vessel endothelium,exciting sympathetic nerve and so on,which takes part in the development of coronary heart disease and MIR injury as well as reflects its pathogenetic condition.NPY can result in MIR injury by impairing coronary artery endothelial function,inducing lipid peroxidation and decreasing ability of myocardial cells to clear oxygen free radicals.更多还原