【摘要】 胃肠道间质瘤(GIST)是发生于胃肠道黏膜下的一种肿瘤,其分子生物学机制是原癌基因c-kit的突变。临床特点为可发生于整个胃肠道,但多发于胃和小肠,临床表现缺乏特异性。影像学检查对判断生物学行为、结构特征等形态学方面有很高价值。免疫组织化学多数表达为CD34、CD117阳性。诊断需要将临床表现、影像学改变、病理形态学和免疫组织化学综合应用。手术是主要治疗方式,而近年来在分子靶向治疗方面取得突破性进展。更多还原

【Abstract】 Gastrointestinal stromal tumors(GIST) is a kind of tumor which originated from gastrointestinal submucosa,of which the molecular biological mechanism is the mutation of proto-oncogene c-kit.Its clinical characteristics is that it can occur in the whole gastrointestinal tract,especily in stomach as well as lack of specific clinical manifestation.Imaging examination has high value in judging morphology questions including its biological behavior,structural feature and so on.Its immunohistochemistry almost shows positive CD34、CD117.Its diagnosis depends on combined application of clinical manifestation,imaging changes,pathological morphology and immunohistochemistry.Surgery is the main therapeutic method although there are great breakthrough in its molecular targeted therapy.更多还原