【摘要】 重症急性胰腺炎仍然具有较高的发病率和病死率,实验和临床研究已经证实氧化应激在急性胰腺炎(AP)发病的早期即已产生,而产生的大量氧自由基作为炎性介质通过影响细胞内和细胞间信号转导通路,在AP的胰腺损伤及伴随的局部或全身并发症中起着至关重要的作用;一些研究报道监测氧化应激指标可以作为预测和评价AP治疗效果的有效指标;但抗氧化剂治疗AP和ERCP术后胰腺炎价值还存在着争议。更多还原

【Abstract】 Severe acute pancreatitis still has high morbidity and mortality.Experimental and clinical studies have demonstrated that oxidative stress has occurred in the early stage of AP,from which oxygen freeradical (OFR) produced play an important role in pancretitis injury of AP and its local and sustem complication by affecting intracellelar and intercellular signal transduction pathway as a kind of inflammatory factor.Some reports showed that detecting indexes about oxidative stress can be effective indexes in predicting and evaluating the therapeutic effect of AP.But antioxidant therapy in AP and ERCP postoperative pancreatitis is lying in dispution.更多还原