【摘要】 以邻苯二甲酸二异辛酯(DEHP)的浓度分别为100mg/(kg.d),200mg/(kg.d),300mg/(kg.d),400mg/(kg.d)染毒小鼠,探讨该化合物对小鼠肝脏、心脏的ATP酶活性的影响以及可能的作用机制。结果表明,随着邻苯二甲酸二异辛酯染毒剂量的增大,肝脏Na+-K+-ATP酶和Ca2+-Mg2+-ATP酶的活性先呈下降趋势。在200mg/(kg.d)时酶活性下降到最低。当邻苯二甲酸二异辛酯的浓度继续增大时,酶的活性又上升。随着邻苯二甲酸二异辛酯染毒剂量的增大,心脏的Na+-K+-ATP酶和Ca2+-Mg2+-ATP酶的活性先呈上升趋势。在200~300mg/(kg.d)时酶活性上升到最高。当邻苯二甲酸二异辛酯的浓度继续增大时,酶的活性又下降。在本实验浓度范围内,邻苯二甲酸酯(Phthalate Esters,PAEs)对小鼠内脏的ATP酶活性有一定影响。更多还原

【Abstract】 To find out the the effect about energy of ATPase on Kunming mice viscera, Kunming mice of experiment group were divided into 4 groups in randomization after 14 days feed and the concentration groups of di-2-ethylhexyl phalate (DEHP) were 100mg/(kg·d),200mg/(kg·d),300mg/(kg·d),400mg/(kg·d) . Along with the increase of DEHP dosage,the energy of Na+-K+-ATPase and Ca2+-Mg2+-ATPase on liver descend,then ascend at 200mg/(kg·d) .Along with the increase of DEHP dosage,the energy of Na+-K+-ATPase and Ca2+-Mg2+-ATPas on heart ascend,then descend at 300 mg/(kg·d).In the range of this experience ,the energy of ATPase on viscera of mice can be influenced by DEHP.更多还原