【摘要】 目的:探讨肝硬化患者血清心钠素(ANP)和甲状腺激素与肝硬化病变程度的相关性。方法:用放射免疫法测定42例不同程度的肝硬化患者血清心钠素及甲状腺激素水平。结果:随着临床肝硬化程度的加重,ANP和反T3(rT3)逐渐升高,而三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、甲状腺素(T4)逐渐下降,且rT3与肝硬化的Child-Pugh记分呈正相关(r=0.53,P<0.01)。结论:肝硬化时,rT3与Child-Pugh记分呈正相关。联合检测ANP和甲状腺激素浓度对预测肝硬化的严重程度及预后有实用价值。更多还原

【Abstract】 Objective: To study the correlation of ANP and thyroxine in patients with different degree of liver cirrhosis.Methods: The concentrations of serum ANP and thyroxine were determined by radioimmunoassay in 42 patients with different degree of liver cirrhosis.Results: It was showed that the serum ANP and rT₃ increased gradually with worsening of clinical liver cirrhosis.But T₃,FT₃,T₄ decreased gradually.What’s more,there was a positive relation between rT₃ and Child-Pugh.Conclusion: It’s suggested that there’s a positive relation between rT₃ and Child-Pugh in liver cirrhosis patients.Measuring the concentration of ANP and thyroxine is of utilizable and reliable clinical value in predicting the degrees and prognosis of liver cirrhosis.更多还原