【摘要】 目的:观察麻醉诱导时重复注射芬太尼对其诱发咳嗽(fentanyl-induced coughing)的影响。方法:300例择期手术患者,麻醉诱导前快速静注芬太尼1μg/kg,出现咳嗽的病人随机分为两组以同样的剂量和方法重复注射芬太尼:2min组在首次给药后2min注射;5min组在首次给药后5min注射。记录咳嗽发生的次数和出现时间,并根据咳嗽次数进行严重程度分级。结果:首次注射芬太尼1μg/kg诱发咳嗽的发生率为18%(54/300)。重复给药后,2min组的发生率为0%(0/27),5min组为40.7%(11/27),2min组发生率明显低于5min组(P<0.01)。咳嗽严重程度组间比较差异有统计学意义(P<0.01)、咳嗽出现时间比较差异无统计学意义(P>0.05)。结论:重复给药可明显降低麻醉诱导时芬太尼1μg/kg诱发的咳嗽发生率,但不影响其程度,而且随着给药间隔的延长,咳嗽发生率逐渐上升。更多还原

【Abstract】 AIM:To observe the effects of repeated intravenous administration of fentanyl 1 μg/kg on fentanyl-induced coughing during anesthesia induction. METHODS: 300 patients with ASA Ⅰor Ⅱ for elective procedures, received an intravenous injection of fentanyl 1 μg/kg via a peripheral cannula prior to anesthesia induction. The patients who experienced cough were randomly divided into two equal groups according to the interval of repeated administration: group 2 min received the same dosage of fentanyl 2 min later and group 5 min was administrated the same dosage of fentanyl 5 min later. The occurrence of cough was recorded. The level of cough was graded. RESULTS: The incidence of fentanyl-induced cough in the first administration was 18% (54/300).After repeated administration, the occurance of cough in group 2 min (0%,0/27) was lower than that in group 5 min (40.7%,11/27) (P<0.01). There was significant difference on the severity between two groups (P<0.01). CONCLUSION: The incidence of fentanyl-induced coughing was significantly decreased after repeated administration of fentanyl 1 μg/kg during anesthesia induction, but the incidence of cough may be increased with the prolonging of the dosing interval.更多还原