【摘要】 为寻找新型昆虫生长调节活性化合物,设计合成了15个未见文献报道的5-芳甲氧基取代的3(2H)-哒嗪酮衍生物,所有化合物结构均通过1H NMR,IR和元素分析确证.初步生物活性研究表明,化合物8o对2龄家蝇幼虫有明显的抑制作用;化合物8a,8c,8g和8j对3龄蝗蝻显示出较好的生物活性.对目标化合物的构效关系亦进行了初步探讨.更多还原

【Abstract】 In order to search for new insect growth regulators, fifteen new compounds containing 5-oxo-3(2H)-pyridazinone derivatives were designed and synthesized. Their structures were confirmed by 1H NMR, IR spectra and elemental analysis. In the preliminary bioassay test, compound 8o obviously disrupted the development of second-instar housefly larvae. Compounds 8a, 8c, 8g and 8j also showed good activity against the third-instar nymphs of locusts (Locusta migratoria manilensis). The structure-activity relationship of compounds was also discussed.更多还原